FIG. 6.

The FDP concentration measured in the interstitial fluid of the construct is higher than the FDP concentration measured in the overlying medium. FDP were measured in the medium or interstitial fluid daily for 1 week. Higher concentrations of FDP were present in the interstitial fluid than in the medium for constructs in 3 mM ACA based on one-way analysis of variance (p < 0.05). Values are mean ± range/2 for n = 2. Medium changes occurred on days 3 and 6, as indicated by squares in the figure; the FDP sampling was done immediately before the medium change, resulting in medium values that were lower on the following day.