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Carbachol dose–response curves from both control animals and at 2, 4, and 8 weeks post-STC. Responses have been normalized to strip weight. Total area under the curve values were 312.8 for controls, 54.65 at 2 weeks, 61.86 at 4 weeks, and 119.7 at 8 weeks post-STC. Maximal steady state (*Emax) values for all STC animals are significantly lower than control tissue (p < 0.001). Emax values at 8 weeks post-STC are significantly higher than 2 and 4 weeks time points (p < 0.05).
