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. Author manuscript; available in PMC: 2010 Sep 29.
Published in final edited form as: Toxicol In Vitro. 2009 Aug 29;24(2):669–676. doi: 10.1016/j.tiv.2009.08.019

Table 2.

Skin irritation effects of un-occlusive dermal exposures of aliphatic hydrocarbons in hairless rats.

Aliphatic hydrocarbon (HC) TEWL (g/m2/h)
24 h 48 h 72 h
TEWL (n = 5–6)
Control 5.6 ± 1.16 4.78 ± 0.66 5.04 ± 0.58
Nonane 8.37 ± 1.20 10.33 ± 3.84 11.04 ± 3.58
Decane 7.20 ± 2.98 7.75 ± 2.04 10.99 ± 2.76
Dodecane 9.08 ± 2.25 10.60 ± 2.05 11.14 ± 1.11
Tridecane 17.47 ± 4.88 23.54 ± 4.62 36.20 ± 9.54
Tetradecane 11.86 ± 1.72 22.15 ± 6.13 34.04 ± 8.19
Hexadecane 19.63 ± 3.06 47.30 ± 7.96 52.61 ± 8.45
Aliphatic hydrocarbon (HC) Erythema
24 h 48 h 72 h
Erythema (n = 6)
Control 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
Nonane 0.50 ± 0.55 0.50 ± 0.53 0.88 ± 0.64
Decane 0.00 ± 0.00 0.63 ± 0.52 0.50 ± 0.53
Dodecane 0.83 ± 0.75 1.13 ± 0.35 1.25 ± 0.46
Tridecane 1.00 ± 0.00 2.00 ± 0.00 2.83 ± 0.41
Tetradecane 1.33 ± 1.03 2.50 ± 0.53 2.88 ± 0.64
Hexadecane 3.00 ± 0.00 3.00 ± 0.00 4.00 ± 0.00