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. Author manuscript; available in PMC: 2011 May 20.
Published in final edited form as: Cell Host Microbe. 2010 May 20;7(5):412–419. doi: 10.1016/j.chom.2010.04.004

Figure 1.

Figure 1

Induction of pyroptosis by L. monocytogenes. Cell death (A) and IL-1β (B) were measured following a 6 hour infection at an MOI of 5 with the indicated strains in wild type, caspase-1−/−, ASC−/−, Nlrp3−/− or Nlrc4−/− bone marrow-derived macrophages. Data are presented as the average of at least 3 independent experiments and the error bars represent the standard deviation of the mean. Intracellular growth of wild type L. monocytogenes (solid line), Δlmo2473 mutant (dotted line) and Δlmo2473 mutant complement (dashed line) was quantified in wild type C57BL/6. *indicates these values are statistically different with a p value <0.05 using a one-way ANOVA followed by a post-hoc LSD analysis (C) or caspase-1−/− bone marrow-derived macrophages (D). Growth curves are representative of at least three independent experiments. *indicates these values are statistically different with a p value <0.05 using a Students’ t-test