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A two-pronged model for α7 nAChR neuroprotection in early AD. 1, Low concentrations of Aβ oligomer assemblies can activate α7 nAChRs, leading to ERK MAPK activation that couples to neuroprotective signaling and maintenance of the cholinergic phenotype. 2, The high-affinity interaction between Aβ and the α7 nAChR leads to prolonged association, thereby retarding additional Aβ oligomerization as well as preventing toxic interactions with other hippocampal targets.
