FIG. 7.

Acute phase cytokine response in the livers of neonatal IFN-γ^−/−, IFN-γR^−/−, and IL-12p35^−/− mice after i.n. C. muridarum challenge. Groups (n = 3–4) of 1-day-old (A) BALB/c and IFN-γ^−/− and (B) C57BL/6, IFN-γR^−/−, and IL-12p35^−/− mice were challenged i.n. with 100 IFU of C. muridarum. The livers were collected at the indicated time periods and the induction of IL-1β (A and B); or TNF-α (C and D) were quantitated by ELISA. Results are expressed as mean ± SD from each animal group. *P ≤ 0.05 between C. muridarum-challenged BALB/c and IFN-γ^−/−, C57BL/6 and IFN-γR^−/−, or C57BL/6 and IL-12p35^−/− mice. All results are representative of 2 independent experiments.