Figure 8.

Changes in muscle–muscle adhesion caused by expression of a constitutively active DER (λ-egfr) are sensitive to the presence of Vg. (A) Many small adhesion sites were formed between the midline-crossing muscles in slit² mutant embryos (arrowhead) when λ-egfr is expressed in developing muscle cells (Dmef2>λ-egfr) (arrowhead, inset). (B) Expression of λ-egfr in developing muscle cells where Vg function was inhibited by SDΔTEA produced fewer of these ectopic adhesions (arrowhead; inset). (C) Relatively more and larger ectopic adhesions were formed when embryonic muscle cells were overexpressing both λ-egfr and Vg (arrowhead, inset). Insets are close-ups of the area framed by the dotted lines.