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. 2010 Oct 1;21(19):3352–3361. doi: 10.1091/mbc.E10-02-0109

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 5. — The absence of polymerization-competent actin monomers leads to the delocalization of Lmod, but not Tmod. (A). Representative immunolocalization of Lmod (left panel) and Tmod (right panel) in cardiomyocytes after 15-min treatment with 20 μM LatB. Cells were costained with phalloidin to visualize F-actin and with an antibody against the Z-disk protein α-actinin. Bars, 10 μm. (B) Analysis of Tmod and Lmod localization 5/15/30 min after treatment with 20 μM LatB. Incubation of cardiomyocytes with LatB induces rapid dissociation of Lmod from sarcomeres, whereas the localization of Tmod was not affected. For each experiment, >200 cells were analyzed. Data represent averages from three independent experiments; error bars, ±SEM. (C) LatB treatment induces Lmod delocalization to the perinuclear region of cardiomyocytes, as well as to rods inside the nucleus (arrowheads). Bars, 10 μm.