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. 2010 Oct 1;21(19):3352–3361. doi: 10.1091/mbc.E10-02-0109

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 7. — Subcellular localization of Lmod mutants lacking the tropomyosin-binding site and the basic patch. (A) Schematic representation of the GFP-Lmod constructs used in this study. Localization in cardiomyocytes of GFP-tagged Lmod_FL (B), Lmod_44-495 (C), and Lmod_44-495(5xGS) (D). Insets display selected regions of the cells at higher magnification, highlighting the localization pattern of each protein in myofibrils. Lmod_FL shows striated localization along myofibrils, with distinguishable accumulation near M-lines. Lmod_44-495 shows diffuse localization along myofibrils, with a large fraction localizing to the nucleus (E). Lmod₄₄(5xGS) displays a striated pattern along myofibrils but, in contrast to Lmod_FL, it does not accumulate near M-lines. The cells were also stained with rhodamine-phalloidin to visualize F-actin. Bars, 10 μm.