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AMPKα, like LKB1, requires Ran-GTP hydrolysis for nuclear import. HEK 293 cells transiently transfected with constructs expressing two fused GFP molecules (2xGFP), GFP-tagged full-length AMPKα2, truncated AMPKα2 (AMPKαΔC) or LKB1, with or without the GTP-hydrolysis defective Ran mutant RanQ69L. Nuclei are stained with DRAQ5 (blue). Bar, 10 μm.
