Table 3.
Association of Magnetic Resonance Imaging Measures to Global Cognitive Function and 5 Different Cognitive Domainsa
| Total Sample (N = 575) |
No Dementia (n = 494) |
Dementia (n = 81) |
||||
|---|---|---|---|---|---|---|
| Cognitive Function, Model Term | Estimate (SE) | P Value | Estimate (SE) | P Value | Estimate (SE) | P Value |
| Global cognitive function | ||||||
| WMHV | −0.108 (0.018) | <.001 | −0.058 (0.015) | <.001 | −0.035 (0.049) | .48 |
| 1 Infarct | 0.043 (0.047) | .37 | 0.016 (0.039) | .68 | 0.090 (0.117) | .43 |
| >1 Infarct | −0.215 (0.067) | .002 | −0.154 (0.059) | .009 | −0.157 (0.138) | .26 |
| TBV | 0.032 (0.005) | <.001 | 0.017 (0.004) | <.001 | 0.035 (0.009) | <.001 |
| Episodic memory | ||||||
| WMHV | −0.125 (0.022) | <.001 | −0.080 (0.020) | <.001 | 0.033 (0.064) | .61 |
| 1 Infarct | 0.104 (0.059) | .08 | 0.045 (0.051) | .38 | 0.282 (0.152) | .07 |
| >1 Infarct | −0.238 (0.085) | .005 | −0.159 (0.077) | .04 | −0.249 (0.174) | .16 |
| TBV | 0.029 (0.006) | <.001 | 0.010 (0.006) | .07 | 0.034 (0.012) | .007 |
| Semantic memory | ||||||
| WMHV | −0.099 (0.023) | <.001 | −0.047 (0.021) | .03 | −0.115 (0.080) | .16 |
| 1 Infarct | 0.040 (0.059) | .054 | 0.019 (0.054) | .718 | −0.038 (0.187) | .84 |
| >1 Infarct | −0.179 (0.084) | .04 | −0.155 (0.081) | .06 | −0.126 (0.215) | .56 |
| TBV | 0.031 (0.006) | <.001 | 0.017 (0.006) | .004 | 0.047 (0.014) | .001 |
| Working memory | ||||||
| WMHV | −0.022 (0.024) | .006 | −0.022 (0.024) | .37 | −0.036 (0.075) | .63 |
| 1 Infarct | −0.019 (0.063) | .76 | −0.040 (0.063) | .53 | −0.031 (0.182) | .87 |
| >1 Infarct | −0.051 (0.216) | .03 | −0.170 (0.096) | .08 | −0.051 (0.216) | .81 |
| TBV | 0.029 (0.006) | <.001 | 0.016 (0.070) | .02 | 0.035 (0.015) | .02 |
| Perceptual speed | ||||||
| WMHV | −0.156 (0.028) | <.001 | −0.103 (0.028) | <.003 | −0.011 (0.071) | .88 |
| 1 Infarct | −0.205 (0.172) | .57 | 0.033 (0.074) | .65 | 0.205 (0.172) | .24 |
| >1 Infarct | −0.375 (0.106) | 0.1 | −0.325 (0.116) | .004 | −0.102 (0.199) | .61 |
| TBV | 0.053 (0.007) | <.001 | 0.041 (0.008) | <.001 | 0.033 (0.014) | .02 |
| Visuospatial ability | ||||||
| WMHV | −0.110 (0.024) | <.001 | −0.066 (0.024) | .006 | −0.098 (0.077) | .21 |
| 1 Infarct | −0.051 (0.063) | .43 | −0.069 (0.626) | .27 | −0.060 (0.195) | .76 |
| >1 Infarct | −0.123 (0.091) | .18 | −0.088 (0.095) | .36 | 0.058 (0.225) | .80 |
| TBV | 0.033 (0.006) | <.001 | 0.022 (0.007) | <.001 | 0.032 (0.015) | .04 |
Abbreviations: TBV, total brain volume (TBV = total brain parenchymal volume/total cranial volume); WMHV, white matter hyperintensity volume (WMHV = natural log [white matter hyperintensity volume/total cranial volume]).
a
Estimated from separate linear regression models that controlled for age, sex, education, race, and time elapsed between clinical evaluation and magnetic resonance imaging. The α level was set at .008 to account for the 6 outcome measures (ie, .05/6 = .008).