Table 2. Common variants implicated in recent candidate gene and GWAS studies with p<5×10⁻⁸.

Fourteen variants at 13 independent loci are shown; the first two variants are at the same locus but are incompletely correlated and may represent different signals of association. P-values for variants observed in more than one study (or a close proxy) are based on meta-analysis of reported studies.

Nearby genes	SNP	Chr	Allele frequency	Trait	Effect (mm Hg)	p-value	Reference
NPPA/NPPB	rs5068	1	0.94	SBP	1.10	3×10−9	[62,63]
MTHFR/CLCN6/NPPA/NPPB	rs17367504	1	0.86	SBP	0.85	2×10−13	[63]
CYP17A1	rs11191548	10	0.91	SBP	1.16	7×10−24	[63,64]
PLCD3	rs12946454	17	0.28	SBP	0.57	1×10−8	[63]
FGF5	rs16998073	4	0.21	DBP	0.50	1×10−21	[63]
c10orf107	rs1530440	10	0.81	DBP	0.39	1×10−9	[63]
SH2B3	rs3184504	12	0.47	DBP	0.46	3×10−18	[63,64]
CYP1A2/CSK/LMAN1L	rs1378942	15	0.36	DBP	0.43	1×10−23	[63,64]
ZNF652	rs16948048	17	0.39	DBP	0.31	5×10−9	[63]
PLEKHA7	rs381815	11	0.26	SBP	0.65	2×10−9	[64]
ATP2B1	rs2681492	12	0.80	SBP	0.85	6×10−17	[64,65]*
ULK4	rs9815354	3	0.17	DBP	0.49	3×10−9	[64]
CACNB2	rs11014166	10	0.66	DBP	0.37	1×10−8	[64]
TBX3/TBX5	rs2384550	12	0.65	DBP	0.35	4×10−8	[64]

^*A correlated SNP was reported in Cho et al just missed genome-wide significant association with SBP (P=1×10⁻⁷).