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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Lab Invest. 2010 Jun 28;90(10):1415–1424. doi: 10.1038/labinvest.2010.117

Figure 1. ErbB4 stimulates COX-2 expression in colon epithelial cells.

Figure 1

(A) YAMC cells were infected with retroviral vectors expressing each ErbB4 isoform (A1, JM-a/CYT-1; A2, JM-a/CYT-2; B1, JM-b/CYT-1; B2, JM-b/CYT-2). Whole cell lysates were prepared and subjected to Western blot analysis for full-length (FL) ErbB4 and COX-2 expression. Actin blot included as loading control. (B) JM-b/CYT-2 expressing cells (YAMC-ErbB4) were exposed to HRG (100 ng/ml) for 3h; COX-2 protein levels were determined by immunoblot analysis. (C) MDCK cells were infected with Vector or ErbB4-expressing constructs and COX-2 levels were determined by Western blot analysis.