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. Author manuscript; available in PMC: 2011 Sep 28.
Published in final edited form as: ACS Nano. 2010 Sep 28;4(9):5217–5224. doi: 10.1021/nn101427t

Figure 2.

Figure 2

Fluorescence of NIR dyes in vitro (A) and dye-loaded MNPs in vivo (B). A small amount (3 μl) of each hydrophobic dye in ethanol was dropped onto filter paper and the fluorescence intensity measured with manually drawn ROIs. Magnetic nanoparticles containing 0.25–5.0% w/w dye were suspended in mannitol citrate buffer (1 mg MNPs/mL) and 20 μL was subcutaneously injected and immediately imaged. Representative images are shown for dye 2826 in ethanol (C), and a mouse subcutaneously injected with MNPs loaded with dye 5700 at 0.25, 0.5, and 1.0% w/w dye in 1 mg/mL MNPs (D).