Fig. 1.

Effects of AP5 and CNQX on the amplitude and frequency of sEPSCs in rat LC neurons. The holding potential in this and all following experiments was −80 mV. A Representative recording of sEPSCs and their abolition by a combination of the NMDA- and non-NMDA receptor antagonists AP5 (50 μM) and CNQX (10 μM), respectively. B Percentage change by these antagonists of the normalised sEPSC amplitude and frequency, expressed as mean ± S.E.M. values (n = 4). *P < 0.05; statistically significant differences from the control data, 8–10 and 13–15 min after drug application