Fig. 2.

Facilitation by 2-MeSATP of the sEPSC frequency, but not amplitude in rat LC neurons. Aa Representative recordings of sEPSCs before (Ab, left panel) and 8–10 min after (Bb, right panel) starting superfusion with 2-MeSATP (300 μM). Note the different time-scales of recording in Aa and Ab as well as the transient inward current induced by 2-MeSATP in Aa. Change of the absolute amplitude (Ba) and frequency (Bb) of the sEPSCs before, during and after the application of 2-MeSATP (mean ± S.E.M. of seven experiments). The time-period elapsing from the beginning of superfusion with 2-MeSATP is indicated. ^#P < 0.05; statistically significant difference from the control value