Table 5.
Healing rate (after first treatment and final) in major series reported in the literature according to different methods of treatment
| Author/year of publication | Number of patients | Type of treatment | Healing rate after first treatment (%) | Final healing rate (%) | Followup (years) | Observations |
|---|---|---|---|---|---|---|
| Neer et al./1966 [27] | 45 | Observation | – | 8 | 1–10 | 1–3 refractures occurred in 80% of cases |
| 129 | Curettage/grafting | NR | 52 | 2–10 | Any site and any age included | |
| Spence et al./1976 [34] | 144 | Curettage/grafting | 75 | NR | 1–4 | Underline the use of freeze-dried cancellous bone as packing material |
| Scaglietti et al./1979 [32] | 72 | Steroid injection | NR | 90 | 1–3 | More than one steroid injection of 40 to 200 mg according to the cyst volume |
| Scaglietti et al./1982 [33] | 163 | Steroid injection | NR | 24 | NR | Long-term results |
| Capanna et al./1982 [4] | 95 | Steroid injection | NR | 80 | 1–5 | From 2–7 injections every 2 months until evidence of cyst response. Neer modified |
| Campanacci et al./1986 [3] | 178 | Curettage/grafting | NR | 67 | 1–8 | Same as above. Longer followup |
| 141 | Steroid injection | NR | 68 | |||
| Farber and Stanton/1990 [11] | 19 | Curettage/grafting | 53 | 95 | 4.1 (av) | Younger age in curettage and bone grafting than steroid group |
| 17 | Steroid injection | 70 | 76 | 3.3 (av) | ||
| Lokiec et al./1996 [21] | 10 | Native BMI | 100 | 100 | 1–4 | Neer modified. Injection of average 25 ml (from 15 to 50) |
| Delloye et al./1998 [9] | 8 | Native BMI | 87.5 | 100 | 1–4.5 | Neer modified as Capanna et al. Quantity of bone marrow not reported |
| Yandow et al./1998 [42] | 12 | Native BMI | 42 | 67 | 1–6 | Personal classification. 18 ml av of bone marrow injection |
| Chang et al./2002 [5] | 14 | Native BMI | 43 | NR | 1–9 | Personal classification. 12 to 24 ml of bone marrow injection |
| 65 | Steroid injection | 51 | NR | |||
| Rougraff and Kling/2002 [30] | 23 | DBM + native BMI | 78 | 70 | 1–7 | Neer classification. 5 to 32 ml of bone marrow av 18 |
| Kanellopoulos et al./2005 [18] | 19 | DBM + native BMI | NR | 89.5 | 1–3.8 | Underline the role of reaming of the cyst. Neer classification |
| Cho et al./2007 [6] | 28 | Native BMI | 52 | 87 | 2–15 | Final 2.19 injections in steroid group versus 1.57 in the marrow injection group. 12 – 50 ml of bone marrow injection |
| 30 | Steroid injection | 23.3 | 92 | |||
| Sung et al./2008 [35] | 94 | Steroid injection | 16 | NR | 7 (av) | Neer classification. Quantity of bone marrow and steroid not specified |
| 39 | Curettage | 36 | NR | 9 (av) | ||
| 34 | Steroid injection + DBM + native BMI | 50 | NR | 4 (av) | ||
| Wright et al./2008 [41] | 45 | Steroid injection | 42 | 42 | 0–2 | Neer classification modified. 9 to 18 ml of bone marrow injection |
| 39 | Native BMI | 23 | 23 | |||
| Zamzam et al./2009 [43] | 28 | Native BMI | 57 | 82 | 2.5–3.5 | 20 ml av of bone marrow injection. Personal classification |
| Di Bella et al. [current study] | 143 | Steroid injection | 21 | 38 | 4 (av) | Neer classification. 10 cc of bone marrow concentrate |
| 41 | DBM + BMC | 59 | 71 | 1.8 (av) |
DBM = demineralized bone matrix; Native BMI = bone marrow injection without concentration; BMC = bone marrow concentrate injection; NR = not reported; av = average.