C. elegans germline and the expression of OMA-1/2 and PIE-1 proteins. Spatial and temporal expression of OMA-1/2 (green, left) and PIE-1 (blue, right) proteins in the gonad and embryos during the C. elegans lifecycle. The embryonic stages when each protein represses transcription are contained within the dashed lines (light orange, direct repression; orange, indirect repression). Red arrow, MBK-2 activation; P0-P4, germline blastomeres; Sp, spermatheca; Z2/Z3, primordial germ cells in L1.