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Class IV mutants exhibited extremely altered activation pattern. A and B, Control anterior activation pattern and vECG. C through F, Activation maps and vECGs from class IV mutants showed breakthroughs along the anterior septal surface (C and E) with either normal (D; 37 ms) or prolonged (F; 53 ms) PR intervals. P indicates atrial depolarization; QRS, QRS depolarization; A, apex; RV, right ventricle; and LV, left ventricle.
