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. Author manuscript; available in PMC: 2011 Sep 15.

Published in final edited form as: Bioorg Med Chem. 2010 Aug 1;18(18):6695–6700. doi: 10.1016/j.bmc.2010.07.061

Effect of L-lysine co-injection on the tumor and kidney uptakes of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH and ^99mTc-RGD-Arg-(Arg¹¹)CCMSH at 2 h post-injection. The white (□) and light grey () columns represented the tumor and renal uptakes of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH with or without L-lysine co-injection. The heavy grey () and black (■) columns represented the tumor and renal uptakes of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH with or without L-lysine co-injection. L-lysine co-injection significantly (*p<0.05) reduced the renal uptakes of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH by 27.7% and ^99mTc-RGD-Lys-(Arg¹¹)CCMSH by 52.1% at 2 h post-injection without affecting the tumor uptakes. Meanwhile, the tumor uptake value of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH was 1.44 times (*p<0.05) the tumor uptake value of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH at 2 h post-injection.

Inline graphic — Effect of L-lysine co-injection on the tumor and kidney uptakes of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH and ^99mTc-RGD-Arg-(Arg¹¹)CCMSH at 2 h post-injection. The white (□) and light grey () columns represented the tumor and renal uptakes of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH with or without L-lysine co-injection. The heavy grey () and black (■) columns represented the tumor and renal uptakes of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH with or without L-lysine co-injection. L-lysine co-injection significantly (*p<0.05) reduced the renal uptakes of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH by 27.7% and ^99mTc-RGD-Lys-(Arg¹¹)CCMSH by 52.1% at 2 h post-injection without affecting the tumor uptakes. Meanwhile, the tumor uptake value of ^99mTc-RGD-Arg-(Arg¹¹)CCMSH was 1.44 times (*p<0.05) the tumor uptake value of ^99mTc-RGD-Lys-(Arg¹¹)CCMSH at 2 h post-injection.