Fig. 2.

Proliferative responses of gliadin-specific T-cell clones stimulated with total gluten extracts from transgenic wheat lines. T-cell clones made from CD patients and specific for the epitopes DQ2-α-II, DQ2-γ-VII, DQ8-α-I, and DQ8-γ-I were stimulated with antigen-presenting cells incubated with serial dilutions of gluten antigen. Transgenic lines derived from line BW208 are depicted in A, whereas transgenic lines derived from BW2003 are depicted in B. The responses of the T-cell clones against total gluten extracts from the relevant wild-type lines are shown with corresponding symbols in the lighter colors.