Table 3.

Regions with increased functional connectivity for Young compared to Elderly adults in top-down and default mode networks.

Region	ROI abbreviation	MNI coordinates (x, y, z)	Z Score
DEFAULT MODE
Posterior cingulate cortex	PCC	8, −56, 30	Initial seed
Frontal medial cortex	FMC	−2, 54, −12	6.38
Left middle temporal gyrus	LMTGa	−52, −18, −18	6.00
Left middle frontal gyrus	LMFG	−30, 20, 50	5.90
Right middle temporal gyrus	RMTGa	58, −10, −18	5.11
Left parahippocampal gyrus	LPHGb	−24, −26, −20	4.03
Left lateral parietal cortex	LLOCc	−44, −72, 34	3.63
Right parahippocampal cortex	RPHGb	24, −26, −20	3.25
Right lateral parietal cortex	RLOCc	54, −62, 32	2.82
FRONTO-EXECUTIVE
Right anterior prefrontal cortex	RALPFC	32, 40, 28	Initial seed
Right insular cortex	RINSd	38, 4, −2	5.38
Left prefrontal cortex	LPFCe	−36, 34, 28	4.90
Right prefrontal cortex	RPFCe	32, 42, 36	4.69
Left insular cortex	LINSd	−38, 8, −4	4.59
Right inferior frontal cortex	RIFGf	34, 48, −6	4.35
Left inferior frontal cortex	LIFGf	−38, 48, 8	3.29
FRONTO-PARIETAL
Right inferior parietal sulcus	RIPS	25, −62, 53	Initial seed
Right ventral visual cortex	RVVISg	36, −62, 0	6.94
Left ventral visual cortex	LVVISg	−44, −62, −6	5.82
Right frontal opercular/insular cortex	RFOI	28, 26, 8	5.12
Right supramarginal gyrus	RSMG	32, −38, 38	3.58
Right lateral occipital cortex	RLOC	26, −64, 54	3.51

ROIs with like subscripts were combined to make bilateral ROIs. See Figure 1 for anatomical visualization of ROIs on PALS-B12 atlas; seed-to-ROI age effects were largely within networks, thus inter-regional relationships for all ROI pairs (where bilateral ROIs taken as single ROI) were examined for subsequent fitness effects.