Table 4.

Regions with increased functional connectivity for Olders compared to Young adults in top-down and default mode networks.

Region	ROI abbreviation	MNI coordinates (x, y, z)	Z Score
DEFAULT MODE
Posterior Cingulate Cortex	PCC	8, −56, 30	Initial seed
Left insular cortex	LINSa	−32, 12, 4	5.43
Right insular cortex	RINSa	30, 14, 4	5.01
Right parietooccipital sulcus	RPS	14, −82, 48	4.69
Left occipital fusiform gyrus	LFGb	−16, −80, −8	4.53
Right occipital fusiform gyrus	RFGb	26, −62, −8	4.41
Right supramarginal gyrus	RSMG	62, −34, 44	4.23
Right precentral gyrus	RPCG	40, −4, 38	3.99
FRONTO-EXECUTIVE
Right anterior prefrontal cortex	RALPFC	32, 40, 28	Initial seed
Left temporal pole	LTP	−44, 20, −24	5.54
Right middle temporal gyrus	RMTGa	70, −14, −16	5.27
Left hippocampus/anterior parahippocampal gyrus	LHC/PHGa	−16, −8,24	5.24
Left hippocampus	LHC	−24, −22, −18	4.94
Ventral frontal medial cortex	FMCv	−8, 54, -18	4.82
Anterior frontal medial cortex	FMCa	−12, 66, 18	4.66
Left middle temporal gyrus	LMTGa	−56, −10, −22	4.03
FRONTO-PARIETAL
Right inferior parietal sulcus	RIPS	25, −62, 53	Initial seed
Left lateral occipital cortex	LLOCa	−56, −68, 36	5.93
Right subcallosal frontal medial cortex	FMCsc	2, 20, −22	5.69
Right lateral occipital cortex	RLOCa	58, −60, 38	5.32
Cingulate gyrus	CG	0, −10, 32	5.16
Posterior cingulate gyrus	PCC	−10, −54, 36	5.04
Frontal medial cortex	FMC	2, 44, 18	4.94
Ventral frontal medial cortex	FMCv	0, 48, 0	4,85

ROIs with like subscripts were combined to make bilateral ROIs; see Figure 1 for anatomical visualization of ROIs on PALS-B12 atlas; since regions in this contrast were not part of the seed's network, only the seed-to-ROI relationships were examined for subsequent fitness effects.