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. 2010 Sep 30;6(9):e1000950. doi: 10.1371/journal.pcbi.1000950

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Chatterjee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Addition of 50 µg/ml of anti-XI and anti-XII will completely prevent initiation of clotting in resting blood showing that initiation is a result of leak past saturated effects of CTI. However, on CVX activated platelets initiation is still unaffected by the presence of both CTI and these antibodies. Initial thrombin production during the propagation phase is however diminished due to abolition of thrombin feedback on FXI. Insert shows initial rates of thrombin formation in the presence of these antibodies.