Table 2. Initial conditions of species in the Platelet-Plasma model.

Species	Hockin-Mann Model Initial Concentration (M)	Platelet-Plasma Model Initial Conditions (M)
TF	0	0
VII	1.0×10−8	1.0×10−8
TF = VII	0	0
VIIa	1.0×10−10	1.0×10−10
TF = VIIa	0	0
Xa	0	0
IIa	0	0
X	1.6×10−7	1.6×10−7
TF = VIIa = X	0	0
TF = VIIa = Xa	0	0
IX	9.0×10−8	9.0×10−8
TF = VIIa = IX	0	0
IXa	0	0
II	1.4×10−6	1.4×10−6
VIII	7.0×10−10	7.0×10−10
VIIIa	0	0
IXa = VIIIa	0	0
IXa = VIIIa = X	0	0
VIIIa1-L	0	0
VIIIa2	0	0
V	2.0×10−8	2.0×10−8
Va	0	0
Xa = Va	0	0
Xa = Va = II	0	0
mIIa	0	0
TFPI	2.5×10−9	2.5×10−9
Xa = TFPI	0	0
TF = VIIa = Xa = TFPI	0	0
ATIII	3.4×10−6	3.4×10−6
Xa = ATIII	0	0
mIIa = ATIII	0	0
IXa = ATIII	0	0
IIa = ATIII	0	0
TF = VIIa = ATIII	0	0
Boc-VPR-MCA	-	1.0×10−5
Boc-VPR-MCA = IIa	-	0
Boc-VPR	-	0
AMC	-	0
XII	-	3.4×10−7
XIIa	-	0
XIIa = XII	-	0
PK	-	4.5×10−7
XIIa = PK	-	0
K = XII	-	0
K	-	0
CTI	-	4.2×10−6
XIIa = CTI	-	0
C1inh	-	2.5×10−6
XIIa = C1inh	-	0
XIIa = ATIII	-	0
XI	-	3.1×10−8
XI = IIa	-	0
XIa	-	0
XIIa = XI	-	0
XIa = ATIII	-	0
XIa = C1inh	-	0
α1AT	-	4.5×10−5
α2AP	-	1.0×10−6
XIa = α1AT	-	0
XIa = α2AP	-	0
XIa = IX	-	0
IXa = X	-	0
Xa = VIII	-	0
VIIa = IX	-	0
VIIa = X	-	0
Fbg	-	9.0×10−6
Fbg = IIa	-	0
Fbn1	-	0
Fbn1 = IIa	-	0
(Fbn1)2	-	0
(Fbn1)2 = IIa	-	0
Fbn2	-	0
Fbn2 = IIa	-	0
(Fbn1)2 = IIa = ATIII	-	0
Fbn1 = IIa = ATIII	-	0
Fbn2 = IIa = ATIII	-	0

The initial conditions for the first 34 values in Table 2, were set to the values used in the Hockin Mann model [18]. The level of Boc-VPR-MCA was set to 10 µM (this is the level of fluorogenic substrate we use in our experiment). The level of CTI was set to 4.2 µM corresponding to the concentration of 50 µg/ml used in the phlebotomy syringe. XII, XI Pre-Kallikrein, C1-Inhibitor, α₁AT, α₂AP and Fibrinogen are set to their plasma concentrations [84], [92], [93].