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. 2010 Sep 30;5(9):e12775. doi: 10.1371/journal.pone.0012775

Table 1. Estimates of the parameters providing the best fit to the simulated and experimental data.

Simulated data Experimental data
Actual Estimated Estimated gamma Estimated SM
Inline graphic 66.7 Inline graphic Inline graphic Inline graphic
Inline graphic 20 Inline graphic Inline graphic Inline graphic
Inline graphic 0 Inline graphic Inline graphic Inline graphic
Inline graphic cells 100 Inline graphic Inline graphic Inline graphic
Inline graphic 0.01 Inline graphic Inline graphic Inline graphic

Left column: fit of the simulated dats with the general model of eqns. (7)(described in the text and Figure 3). Right column: comparison of the fits of the experimental data with either the general model of Eqns. (7) or Smith-Martin model. or Smith-Martin model. Here Inline graphic and Inline graphic are the average times of the first and the following cell divisions, Inline graphic is the delay before any cells undergo their first division, Inline graphic is the initial number of cells, and Inline graphic is the death rate of dividing cells. Standard deviations for parameters were calculated by bootstrapping the residuals 100 times [32], [48]. Simulated data was generated using a log-normal distribution of inter-division times as shown in Fig. 3, with the exponential death rate Inline graphic.