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. 2010 Sep 30;5(9):e13117. doi: 10.1371/journal.pone.0013117

Figure 9. Effect of STAT1-CC and IFN-γ on cell culture grown full-length HCV.

Figure 9

Stable sensitive (S5-15) and resistant (GR17-1) cell lines with or without STAT1 or STAT1-CC were infected with full length HCV genotype 2a clone JFH1 virus at MOI of 1.0. After 72 hours cells were treated with IFN-γ. At 72 hours post-infection total RNA was isolated, positive strand HCV RNA level was measured by real-time RT-PCR. (A) Antiviral effect of IFN-γ and IFN-α against cell culture grown full-length HCV. (B) Demonstrate the antiviral effect of Stat1-CC expression on cell culture derived full-length HCV RNA in sensitive and resistant cells due to IFN-γ treatment. Bars are representative of three independent experiments and error bars represent standard error of the mean. Significance was considered at values below 0.05 (p<0.05, student t-test). Asterisks (*) represent significant (p<0.02) reductions in HCV RNA.