Table 3.
The concentrations of R,S)-Ket, (R,S)-norKet, (R,S)-DHNK, (2R,6R)-/(2S,6S)-HNK, (2S,6S)-HKet and (2S,6R)-HKet in the calibration standards and quality control standards used in the validation of the achiral method in plasma.
| (R,S)-Ket (ng/ml) | (R,S)-norKet (ng/ml) | (R,S)-DHNK (ng/ml) | (2R,6R)-/(2S,6S)-HNK (ng/ml) | (2S,6S)-HKet (ng/ml) | (2S,6R)-HKet (ng/ml) | |
|---|---|---|---|---|---|---|
| Calibration | ||||||
| 1 | 25,000 | 750 | 12,500 | 12,500 | 40 | 30 |
| 2 | 18,750 | 562 | 9,375 | 9,375 | 30 | 22.5 |
| 3 | 12,500 | 375 | 6,250 | 6,250 | 20 | 15 |
| 4 | 6,250 | 188 | 3,125 | 3,125 | 10 | 7.5 |
| 5 | 5,000 | 141 | 2,344 | 2,344 | 7.5 | 5.6 |
| 6 | 3,125 | 63 | 1,563 | 1,563 | 5 | 3.8 |
| QC | ||||||
| High | 21,875 | 656 | 10,938 | 10,938 | 35 | 26 |
| Medium | 15,625 | 469 | 7,813 | 7,813 | 25 | 18 |
| Low | 9,375 | 281 | 4,688 | 4,688 | 15 | 11 |