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Completed phase 2 trials.
| Agent | Date of Trial Completion |
Mechanism of Action |
|---|---|---|
| FAILED | ||
| AN179271,72 | 2003 | Active Aβ immunization |
| SGA-74278 | 2005 | GABAB receptor antagonist |
| Lecozotan SR74 | 2008 | Selective 5-HT1A receptor antagonist |
| SUCCESSFUL | ||
| Huperzine A79,80 | 2007 | ChEI |
| Intravenous immunoglobulin (IVIg)84 | 2008 | Passive immunization |
| Methylthioninium chloride (TRx0014)86,87 | 2008 | Dissolves and inhibits formation of neurofibrillary tangles |
