Figure 1.
Effect of knockout of Nrf2 on male fertility. Males of the indicated Nrf2 genotypes were paired with wild type females for a 20 week continuous breeding study. A) Percentage of males of each genotype that sired the number of litters indicated on the x-axis during the 20 week study. B) The mean ± SEM cumulative number of offspring sired by males of each genotype during 4 week intervals of the 20 week breeding study. Effect of genotype × time interaction, p=0.046 by ANOVA. N = 8, 9, and 6 for Nrf2−/−, Nrf2+/+, and Nrf2+/−, respectively.