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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Genes Immun. 2010 May 13;11(7):554–560. doi: 10.1038/gene.2010.24

Figure 3.

Figure 3

Functional network analysis of methylated genes that are expressed in primary human CD4+ T cells identified involvement in basic cell functions, including cellular signaling and interaction, and cellular growth and proliferation (a). Genes that are methylated and non-expressed are functionally associated with antigen presentation, cell-mediated immune response and humoral immune response (b). Gene key: solid lines indicate direct interaction, dotted lines indicate indirect interaction, an arrow from a to b indicates that a acts on b, a line without an arrowhead indicates binding only and a line with a small vertical line at the end from a to b indicates a inhibits b. Gray indicates genes that are methylated, white indicates genes that are not user specified but incorporated into the network through relationships with other genes. Node shapes are: square, cytokine; diamond (vertical), enzyme; diamond (horizontal), peptidase; dotted rectangular (vertical), ion channel; solid rectangular (vertical), G-protein-coupled receptor; triangle, kinase; oval (horizontal), transcription regulator; oval (vertical), transmembrane receptor; trapezoid, transporter; circle, other.