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. Author manuscript; available in PMC: 2011 Mar 30.
Published in final edited form as: Oncogene. 2010 Jul 12;29(39):5370–5380. doi: 10.1038/onc.2010.269

Figure 3. Inhibiting EZH2 function de-represses SLIT2.

Figure 3

(a) SLIT2 expression is up-regulated by a histone deacetylase (HDAC) inhibitor SAHA. Prostate cancer cell lines LNCaP, PC3 and DU145 were treated with 5 μM of SAHA for 24 and 48 hours, and analyzed by qRT-PCR. (b) Marked up-regulation of SLIT2 by the PRC2-inhibiting compound DZNep. Breast (MDA-MB-231 and SKBR3) and prostate (DU145 and LNCaP) cancer cells were treated with 5 μM DZNep for 48 hours and analyzed by qRT-PCR. Expression of target gene was normalized to the amount of the GAPDH housekeeping gene.