Figure 7. SLIT2 inhibits prostate cancer cell invasion and proliferation.
(a) Immunoblot analysis of SLIT2 in HEK293/SLIT2 stable cells and the control HEK293/pBC cells. (b) SLIT2 overexperssion inhibits LNCaP cell invasion. LNCaP cells were incubated with conditioned medium from HEK293/SLIT2 or HEK293/pBC control cell for 48 hr and subjected to Boyden Chamber Invasion assay. (c) SLIT2 overexpression reduces LNCaP cell proliferation. Cell proliferation assay was performed in LNCaP cells incubated in conditioned medium from HEK293/SLIT2 or HEK293/pBC for 48 and 96 hours.