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. 2010 May 21;95(10):1675–1682. doi: 10.3324/haematol.2010.023481

Figure 4.

Figure 4.

The promoters of miR-196b and HOXA genes have a lower level of methylation in MLL-rearranged precursor B-ALL patients than in non-MLL precursor B-ALL patients and normal bone marrow. (A) Methylation status of the probe covering multiple CpG islands (y-axis) within the 5’ region of miR-196b (27,175,990–27,176,034) was analyzed in nine MLL-rearranged precursor B-ALL patients, 27 non-MLL precursor B-ALL and eight normal bone marrow (BM) samples. Dots represent individual patients *P≤0.01. (B) Heat map displaying methylation status of the HOXA cluster in the same patients as for Figure 4A. Columns represent patients’ samples and rows represent the different HOXA cluster genes. Relative DNA methylation levels are shown in red (high) and blue (low). Gene names are listed at the right. The heat map was generated in GenePattern version 3.1.2.43 MLL-rearranged versus non-MLL precursor B-ALL, P<0.0001; MLL-rearranged precursor B-ALL versus normal BM, P<0.0002.