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Progression-free survival and overall survival by risk group. (A) Progression-free survival. Poor risk: >10% TP53 loss. Intermediate risk: ≤10% TP53 loss and at least one of: unmutated IGHV genes, IGHV3-21 usage, beta-2 microglobulin >4 mg/L, 11q loss >5%. Good risk: ≤10% TP53 loss, none of the intermediate risk factors and mutated IGHV genes. (B) Overall survival.
