Figure 2.
Distribution of CpG dinucleotides in the 5′ region of the KIR3D1 gene. The transcriptional start site is indicated by a square and the CpG dinucleotides are highlighted in gray. Analysis of the methylation patterns of the CpG island surrounding the transcriptional start site of this gene revealed that the methylation status consistently correlates with the transcriptional activity in primary NK cells.17 The primers used in this work to analyze the methylation pattern of this sequence are underlined.