Table 1.
Prognostic markers and scores in peripheral T-cell lymphomas (PTCLs)
| Prognostic indicator | PTCL subtype | Studies |
|---|---|---|
| Histotype | All | The Non-Hodgkin’s Lymphoma Classification Project [2]; Vose et al. [5••]; Savage et al. [6•]; Lopez-Guillermo et al. [8]; Ascani et al. [16] |
| International Prognostic Index (IPI) | All | The Non-Hodgkin’s Lymphoma Classification Project [2] |
| ALCL | Savage et al. [6•]; Falini et al. [20] | |
| ATLL | Suzumiya et al. [21•] | |
| NK/T-cell lymphoma | Au et al [57•] | |
| PIT | PTCL/NOS | Gallamini et al. [22]; Savage et al. [6] |
| Bologna score | PTCL/NOS, AITL | Went et al. [11]; Briones et al. [34] |
| Korean prognostic index | NK/T-cell lymphoma | Lee et al. [54] |
| NK prognostic index | NK/T-cell lymphoma | Suzuki et al. [67] |
| EBV | PTCL/NOS, AITL | Went et al. [11]; Kluin et al. [24]; Dupuis et al. [25] |
| NK/T-cell lymphoma | Au et al. [62]; Cheung et al. [60]; Chim et al. [64]; Huang et al. [65]; Lee et al. [66]; Ng et al. [63] | |
| Proliferation index | PTCL/NOS | |
| Ki-67 | Went et al. [11] | |
| Molecular signature | Cuadros et al. [43•] | |
| Cellular derivation | PTCL/NOS | Went et al. [11]a; Bekkenk et al. [26]; Kojima et al. [27]; Iqbal et al. [48•] |
| NFκB activation | PTCL/NOS | Martinez-Delgado et al. [36]; Ballester et al. [38]; Briones et al. [34] |
| CYP3A | PTCL/NOS | Rodríguez-Antona et al. [49] |
AITL angioimmunoblastic T-cell lymphoma; ALCL anaplastic large-cell lymphoma; ATLL adult T-cell leukemia/lymphoma; NK natural killer; PTCL/NOS peripheral T-cell lymphoma not otherwise specified
aPrognostic impact not statistically significant