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. 2010 Sep 1;1:126–135. doi: 10.7150/jca.1.126

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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p16 inhibits hypoxia-induced cell migration. (A) The breast cancer cells MDA/Tet-on p16 cells were incubated with or without 1 μg/ml Dox for 72 h, followed by cell migration assay as described in M & M section in normoxic and hypoxic conditions. (B) 4T1/Tet-on p16 (or 4T1/p16) cells were incubated with or without 1 μg/ml Dox for 72 h, followed by cell migration assay in hypoxic conditions. The results represent the data from at least two independent experiments, each performed in triplicate.