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. 2009 Oct 29;1:79. doi: 10.3410/B1-79

Figure 2. Inhibitor of apoptosis antagonist compounds (IACs) trigger dimerization-dependent autoubiquitylation and degradation of inhibitors of apoptosis (IAPs).

Figure 2.

When an IAC ‘Smac-mimetic’ (green triangles) is added to cells, it binds to baculoviral inhibitor of apoptosis repeat 2 (BIR2) and BIR3 of cellular IAP 1 (cIAP1). This somehow allows RING dimerisation of cIAP1, which becomes ubiquitylated (black dots) and degraded by the proteasome. Tumour necrosis factor receptor-associated factor 2 (TRAF2) levels are unaffected by addition of IACs.