Table 4.
LSM (SE) change from baseline at week 4 |
||||||
---|---|---|---|---|---|---|
Parameter | N | Lumiracoxib 100 mg od | N | Ibuprofen 600 mg tid | Estimated difference (95% CI) | p-Value |
24-h MDABP* | ||||||
ARB monotherapy | 53 | −2.5 (0.6) | 45 | 1.3 (0.7) | −3.7 (−5.6, −1.9) | < 0.001 |
ACEI monotherapy | 39 | −2.0 (0.9) | 37 | 2.0 (0.9) | −4.0 (−6.6, −1.4) | 0.003 |
Daytime MSABP* | ||||||
ARB monotherapy | 53 | −3.1 (1.3) | 45 | 5.2 (1.4) | −8.3 (−12.2, −4.5) | < 0.001 |
ACEI monotherapy | 39 | −5.3 (1.6) | 37 | 4.1 (1.6) | −9.4 (−13.9, −4.9) | < 0.001 |
Night-time MSABP* | ||||||
ARB monotherapy | 53 | −3.9 (1.2) | 45 | 3.3 (1.3) | −7.2 (−10.6, −3.8) | < 0.001 |
ACEI monotherapy | 39 | −2.9 (1.39) | 37 | 2.5 (1.42) | −5.4 (−9.4, −1.4) | 0.008 |
Daytime MDABP* | ||||||
ARB monotherapy | 53 | −2.2 (0.8) | 45 | 1.4 (0.8) | −3.6 (−5.8, −1.4) | 0.001 |
ACEI monotherapy | 39 | −2.4 (1.1) | 37 | 1.9 (1.1) | −4.3 (−7.4, −1.1) | 0.009 |
Night-time MDABP* | ||||||
ARB monotherapy | 53 | −2.8 (0.7) | 45 | 0.9 (0.7) | −3.7 (−5.6, −1.8) | < 0.001 |
ACEI monotherapy | 39 | −1.0 (1.0) | 37 | 1.9 (1.0) | −2.8 (−5.7, 0.0) | 0.049 |
Change from baseline at week 4.
ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blockers; BP, blood pressure; CI, confidence interval; ITT, intention-to-treat; LSM, least squares mean; MDABP, mean diastolic ambulatory blood pressure; MSABP, mean systolic ambulatory blood pressure; od, once daily; SE, standard error; tid, three times daily.