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. 2009 Jun;19(2):117–128. doi: 10.1089/oli.2008.0177

FIG. 2.

FIG. 2.

Heparin and vitronectin compete with aptamers for binding to PAI-1 in solution. (A) Increasing amounts of heparin compete with aptamers for binding to PAI-1; squares (▪) represent competition with clone WT-1 (PAI-1 concentration, 378 pM), triangles (▴) represent competition with WT-15 (PAI-1 concentration, 888 pM), and circles (•) represent competition with SM-20 (PAI-1 concentration, 3.4 nM). The x-axis shows the concentration of heparin, while the y-axis shows the fraction of RNA bound to PAI-1. (B) Increasing amounts of vitronectin compete with clones for binding to PAI-1; triangles (▴) represent competition with WT-15 (PAI-1 concentration, 888 pM), while circles (•) represent competition with SM-20 (PAI-1 concentration, 2.2 nM). The x-axis shows the concentration of vitronectin, while the y-axis shows the fraction of RNA bound to PAI-1.