Table 1.

Semi-quantitative analysis of amyloid plaques and tau immunoreactive neurons within the hippocampus and lateral entorhinal cortex (LEC) of female 3xTg-AD mice following 16 weeks treatment

	Amyloid plaques1		Tau immunoreactivity1
Treatment	Hippocampus	LEC	Hippocampus	LEC
Control	−	−	+	+
Control	−	−	+	+
Control	−	−	+	+
Control	−	−	+	+
STZ	+++	−	+	+
STZ	++++	+	+	+
STZ	+	−	+	+
Ex-4	++	−	+	+
Ex-4	−	−	+	+
Ex-4	++	+	+	+
STZ+Ex-4	−	−	+	+
STZ+Ex-4	+	−	+	+
STZ+Ex-4	+	−	+	+
STZ+Ex−4	++	+	+	+

¹- no staining present

+ very limited diffuse staining (<10), no clustering

++ small amount of staining (<50), visible clustering

+++ intermediate amount of 6E10 positive staining (<100), with visible clusters

++++ extensive staining (>100), distinct clusters in multiple areas