. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Clin Cancer Res. 2008 Sep 15;14(18):5810–5818. doi: 10.1158/1078-0432.CCR-07-5202

Table 3.

Multivariate analysis of Puma immunoscore and DFS and OS

Variable (n = 416)	DFS		OS

	HR (95% CI)	P^*	HR (95% CI)	P^*
Puma immunoscore (elevated vs negative/low)	0.70 (0.43–1.15)	0.1773	0.59 (0.37–0.94)	0.0371
Histologic grade (3 and 4 vs 1 and 2)^†	1.35 (0.97–1.87)	0.0783	1.43 (1.04–1.97)	0.0321
TNM stage (III vs II)	2.19 (1.34–3.59)	0.0006	2.19 (1.35–3.54)	0.0004
Treatment (effective vs control/ineffective)	0.65 (0.40–1.06)	0.0918	0.65 (0.40–1.04)	0.0815
Age (10-y increase)	1.08 (0.93–1.25)	0.3131	1.19 (1.02–1.39)	0.0237

Likelihood ratio P value adjusted for adjuvant study.

^†

Grade 1 and 2 (well/moderate); grade 3 and 4 (poor/undifferentiated).