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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: J Org Chem. 2010 Sep 3;75(17):6019–6022. doi: 10.1021/jo101051w

Scheme 1. Synthesis of indolizidine scaffolda.

Scheme 1

aReagents and conditions: (a) Et3N, ClCO2Et, THF; then CH2N2. (b) CF3CO2Ag (20 mol%), HN(OMe)Me, Et3N, THF. (c) ethynylmagnesium bromide (5 equiv), THF, 0 °C; then NaHSO4 (aq.). (d) NaI, HCO2H. (e) K2CO3, MeOH.