Table 2.

Univariate analysis in all patients (n = 4,381)

Variable	DFS, HR (95% CI)	P*	OS, HR (95% CI)	P*
Categorical BMI (overall)		0.0477		0.0218
Underweight vs normal	1.08 (0.89–1.31)	0.4336†	1.13 (0.93–1.36)	0.2209†
Overweight vs normal	0.94 (0.84–1.05)	0.2880†	0.93 (0.83–1.03)	0.1623†
Obese vs normal	1.13 (0.99–1.28)	0.0670†	1.13 (0.99–1.28)	0.0622†
Class 1 obese	1.08 (0.94–1.25)	0.2768†	1.10 (0.96–1.27)	0.1785†
Class 2,3 obese	1.23 (1.01–1.49)	0.0370†	1.18 (0.98–1.44)	0.0879†
Stage
II vs III	0.45 (0.39–0.52)	<0.0001	0.47 (0.41–0.53)	<0.0001
Gender
Men vs women	1.05 (0.95–1.15)	0.3348	1.10 (1.00–1.20)	0.0490
Histologic grade‡
Grade 3/4 vs grade 1/2	1.41 (1.24–1.61)	<0.0001	1.43 (1.26–1.63)	<0.0001
Tumor site
Proximal vs distal	0.90 (0.80–1.01)	0.0836	1.02 (0.91–1.15)	0.6984
MMR status
Defective vs intact	0.68 (0.49–0.94)	0.0174	0.71 (0.53–0.96)	0.0252
Age (1-unit increase)	1.00 (0.996–1.004)	0.9007	1.01 (1.005–1.014)	<0.0001
Number of lymph nodes		<0.0001		<0.0001
1–3 vs 0	1.75 (1.50–2.04)		(1.51–2.04)
>3 vs 0	3.57 (3.04–4.20)		3.58 (3.05–4.19)
Treatment status
Effective vs ineffective/none	0.61 (0.52–0.72)	<0.0001	0.69 (0.59–0.81)	<0.0001

^*Score test P value from a Cox regression model after stratifying by study.

^†Wald Χ² P value for the individual categories shown.

^‡Grade1/2: well/moderate differentiation; grade 3/4: poor/undifferentiated.