Table 3.

Multivariate analysis of BMI and OS

All patients (n = 4,366)
Variable	HR (95% CI)	P*
Categorical BMI (overall)		0.0017
Underweight vs normal	1.24 (1.03–1.50)	0.0258†
Overweight vs normal	0.90 (0.80–1.00)	0.0500†
Class 1 obese vs normal	1.07 (0.93–1.23)	0.3717†
Class 2,3 obese vs normal	1.19 (0.98–1.45)	0.0805†
Age	1.01 (1.01–1.02)	<0.0001
Stage (II vs III)	0.47 (0.41–0.53)	<0.0001
Treatment (effective vs control/ineffective)	0.72 (0.62–0.85)	<0.0001
Gender (men vs women)	1.15 (1.04–1.26)	0.0045
Men (n = 2,268)
Variable	HR (95% CI)	P*
Categorical BMI (overall)		0.0021
Underweight vs normal	1.14 (0.81–1.61)	0.4474†
Overweight vs normal	0.82 (0.71–0.95)	0.0063†
Class 1 obese vs normal	0.94 (0.78–1.15)	0.5599†
Class 2,3 obese vs normal	1.35 (1.02–1.79)	0.0391†
Age	1.01 (1.01–1.02)	<0.0001
Stage (II vs III)	0.51 (0.43–0.61)	<0.0001
Treatment (effective vs control/ineffective)	0.64 (0.51–0.80)	<0.0001
Women (n = 2,098)
Variable	HR (95% CI)	P*
Categorical BMI (overall)		0.0674
Underweight vs normal	1.32 (1.05–1.67)	0.0194†
Overweight vs normal	1.01 (0.85–1.19)	0.9366†
Class 1 obese vs normal	1.24 (1.01–1.53)	0.0447†
Class 2,3 obese vs normal	1.11 (0.84–1.45)	0.4651†
Age (1-y increase)	1.01 (1.00–1.02)	0.0052
Stage (II vs III)	0.41 (0.34–0.51)	<0.0001
Treatment (effective vs control/ineffective)	0.83 (0.66–1.04)	0.0948

^*Likelihood ratio P value after stratifying by study.

^†Wald Χ² P value.