Table 2. Levels of chemokines and cytokines in the peripheral blood.
Values represent Median log10pg/ml (range) | |||||||
Critically ill patients | p Valuea | p Valueb | Mild cases | p Valuec | Healthy Controls | Lung Aspirates | |
Pro-Inflammatory Cytokines | |||||||
IL1α | 1.64 (−0.70–3.26) | 0.2061 | 0.0032 | −0.70 (−0.70–3.26) | 0.0312 | −0.70 (−0.70–3.28) | 2.81 (0.48–3.21) |
IL1β | 0.48 (−0.70–1.05) | 0.2639 | 0.0053 | 0.32 (−0.70–1.80) | 0.0006 | −0.70 (−0.70–0.72) | 2.05 (0.48–2.68) |
IL6 | 2.14 (0.40–3.11) | 0.0022 | 0.0000 | 0.32 (−0.70–3.11) | 0.0001 | Undetected | 2.59 (0.48–3.29) |
TNFα | 0.48 (0.48–1.06) | 0.3697 | 0.0000 | 0.70 (−0.70–4.41) | 0.0000 | Undetected | 0.48 (0.48–0.48) |
IL17 | 0.48 (−0.70–2.14) | 0.2608 | 0.0002 | 0.18 (0.08–1.62) | 0.0000 | −0.70 (−0.70–0.61) | 0.48 (0.48–1.07) |
Anti-Inflammatory Cytokines | |||||||
IL1RA | 1.23 (−0.70–3.20) | 0.0220 | 0.0000 | 0.82 (−0.70–1.84) | 0.0001 | Undetected | 2.55 (0.48–3.01) |
IL2RA | 0.91 (−0.01–1.18) | 0.4438 | 0.0000 | −0.10 (−0.10–2.92) | 0.0000 | Undetected | 2.27 (0.48–2.58) |
IL10 | 1.71 (−0.70–2.59) | 0.0135 | 0.0000 | −0.70 −0.70–2.38) | 0.0011 | Undetected | 0.48 (0.48–2.59) |
Th-1 Cytokines | |||||||
IL2 | 0.48 (0.01–1.31) | 0.0002 | 0.0000 | −0.70 (−0.70–0.53) | 0.0032 | Undetected | 0.48 (0.48–2.52) |
IL12p70 | 0.26 (−0.70–0.32) | 0.6705 | 1.0000 | 0.20 (0.05–0.32) | 0.4417 | 0.20 (0.05–0.32) | 0.48 (0.48–2.74) |
IL12p40 | 0.48 (−0.70–2.76) | 0.2655 | 0.0000 | 0.32 (0.08–2.18) | 0.0000 | Undetected | 2.40 (0.48–2.74) |
Chemokines | |||||||
CXCL5 | 3.30 (−0.70–3.71) | 0.1580 | 0.0001 | −0.70 (−0.70–3.55) | 0.0039 | Undetected | 2.92 (1.13–3.78) |
CXCL8 | 1.37 (−0.70–3.63) | 0.5150 | 0.0000 | 1.10 (0.20–3.65) | 0.0000 | Undetected | 4 (0.48–4.04) |
MIF | 3.33 (3.13–4.24) | 0.4368 | 0.0072 | 3.45 (3.13–4.05) | 0.0009 | 3.08 (2.11–3.69) | 4.18 (1.08–5.42) |
CCL3 | 1.66 (−0.70–2.25) | 0.0224 | 0.0000 | −0.70 (−0.70–2.28) | 0.0032 | Undetected | 1.54 (0.48–2.80) |
CCL4 | 1.89 (−0.70–2.84) | 0.0495 | 0.0000 | 1.57 (−0.70–2.0) | 0.0001 | Undetected | 2.59 (0.08–3.43) |
TRAIL | 0.15 (−0.70–3.09) | 0.2866 | 0.0032 | 0.15 (−0.70–3.09) | 0.0012 | −0.70 (−0.70–3.51) | 1.89 (−0.30–2.76) |
a* p value between critically ill patients and mild cases.
b* p values between critically ill patients and healthy controls.
c* p values between mild cases and healthy controls.