Figure 3. Specific activity of enzymes of the ethylmalonyl-CoA pathway and their regulation.

Enzymes: PhaA, β-ketothiolase; PhaB, acetoacetyl-CoA reductase; CroR, crotonase; Ccr, crotonyl-CoA carboxylase/reductase; Epi, ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Ecm, ethylmalonyl-CoA mutase; Msd, methylsuccinyl-CoA dehydrogenase; Mcd, mesaconyl-CoA hydratase; Mcl1, malyl-CoA/β-methylmalyl-CoA lyase. The y axis is in nmol min⁻¹ mg⁻¹ protein. M, methanol grown cells; A, acetate grown cells; S, succinate grown cells.