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. 2010 Oct 1;5(10):e13118. doi: 10.1371/journal.pone.0013118

Figure 5. Increase of Ih by SKF83959 was independent of activation of D1-like receptors.

Figure 5

The neurons were held at −45 mV, and Ih current was elicited with 1.5-s hyperpolarizing voltage steps to −105 mV every 30 sec. In each panel, the amplitude of Ih was plotted against time. The black bars denotes the perfusion with SKF83959 (50 µM), whereas the gray bar denotes the application of various agents: A. perfusion with D1-like receptor antagonist SCH23390 (10 µM), n = 11; B. Intracellular dialysis of GDP-beta-S (0.5 mM), n = 9; C. intracellular dialysis of GppNHp (0.5 mM), n = 6; D. intracellular dialysis of high concentrations of cAMP (100 µM), n = 6; E. intracellular dialysis of Rp-cAPM (100 µM), n = 6.