Table 2.
50% Cytotoxic concentrations of olomoucine II and roscovitine in HFFF and A549 cellsa
HFFF cells |
A549 cells |
|||
---|---|---|---|---|
Treatment duration, h | Olomoucine II | Roscovitine | Olomoucine II | Roscovitine |
24 | >100 | >100 | ND | ND |
48 | 73 ±4 | 84 ±5 | >100 | >100 |
72 | 16 ±2 | 21 ±2 | ND | ND |
96 | 17 ±2 | 22 ±2 | >100 | >100 |
120 | ND | ND | >100 | >100 |
168 | 16 ±3 | 30 ±4 | ND | ND |
Values are 50% cytoxic concentrations (CC50; μM) ±SD.
n=2. HFFF, human fetal foreskin fibroblast; ND, not